Blum, 50 patient nitazoxanide late treatment RCT: 67% lower mortality [p=0.25], 62% lower ventilation [p=0.17], 20% lower severe cases, and 56% shorter hospitalization [p=0.02] https://c19p.org/blum
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Nitazoxanide superiority to placebo to treat moderate COVID-19 – A Pilot prove of concept randomized double-blind clinical trial
et al., EClinicalMedicine, doi:10.1016/j.eclinm.2021.100981 (preprint 1/22)
RCT with 25 nitazoxanide patients and 25 control patients, showing improved virological and clinical outcomes with treatment.Authors also perform an in vitro study in Vero E6 cells showing 90% inhibition with 0.5µM, with no cytotoxicity. NCT04348409.
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risk of death, 66.7% lower, RR 0.33, p = 0.25, treatment 2 of 25 (8.0%), control 6 of 25 (24.0%), NNT 6.3.
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risk of mechanical ventilation, 62.5% lower, RR 0.38, p = 0.17, treatment 3 of 25 (12.0%), control 8 of 25 (32.0%), NNT 5.0.
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relative severity scores, 20.2% better, RR 0.80, treatment 25, control 25.
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hospitalization time, 55.7% lower, relative time 0.44, p = 0.02, treatment 25, control 25.
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risk of no viral clearance, 89.8% lower, RR 0.10, p = 0.03, treatment 0 of 23 (0.0%), control 4 of 19 (21.1%), NNT 4.8, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 21.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Blum et al., 1/22/2021, Double Blind Randomized Controlled Trial, Brazil, South America, peer-reviewed, 17 authors, trial NCT04348409.
Late treatment
is less effective
is less effective
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