Blum: Nitazoxanide superiority to placebo to treat moderate COVID-19 – A Pilot prove of concept randomized double-blind clinical trial

Blum, 50 patient nitazoxanide late treatment RCT: 67% lower mortality [p=0.25], 62% lower ventilation [p=0.17], 20% lower severe cases, and 56% shorter hospitalization [p=0.02] https://c19p.org/blum

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Nitazoxanide superiority to placebo to treat moderate COVID-19 – A Pilot prove of concept randomized double-blind clinical trial

Blum et al., EClinicalMedicine, doi:10.1016/j.eclinm.2021.100981 (date from earlier preprint), NCT04348409 (history)

22 Jan 2021 Source PDF Share Tweet

RCT with 25 nitazoxanide patients and 25 control patients, showing improved virological and clinical outcomes with treatment.

Authors also perform an in vitro study in Vero E6 cells showing 90% inhibition with 0.5µM, with no cytotoxicity. NCT04348409 (history).

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risk of death, 66.7% lower, RR 0.33, p = 0.25, treatment 2 of 25 (8.0%), control 6 of 25 (24.0%), NNT 6.3.

risk of mechanical ventilation, 62.5% lower, RR 0.38, p = 0.17, treatment 3 of 25 (12.0%), control 8 of 25 (32.0%), NNT 5.0.

relative severity scores, 20.2% better, RR 0.80, treatment 25, control 25.

hospitalization time, 55.7% lower, relative time 0.44, p = 0.02, treatment 25, control 25.

risk of no viral clearance, 89.8% lower, RR 0.10, p = 0.03, treatment 0 of 23 (0.0%), control 4 of 19 (21.1%), NNT 4.8, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 21.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Blum et al., 22 Jan 2021, Double Blind Randomized Controlled Trial, Brazil, peer-reviewed, 17 authors, trial NCT04348409 (history).

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Late treatment
is less effective

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