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0 0.5 1 1.5 2+ Mortality 67% Improvement Relative Risk Ventilation 62% Severity scores 20% no CI Hospitalization time 56% Viral clearance 90% c19nitazoxanide.com Blum et al. NCT04348409 Nitazoxanide RCT LATE TREATMENT Favors nitazoxanide Favors control
Blum, 50 patient nitazoxanide late treatment RCT: 67% lower mortality [p=0.25], 62% lower ventilation [p=0.17], 20% lower severe cases, and 56% shorter hospitalization [p=0.02] https://c19p.org/blum
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Nitazoxanide superiority to placebo to treat moderate COVID-19 – A Pilot prove of concept randomized double-blind clinical trial
Blum et al., EClinicalMedicine, doi:10.1016/j.eclinm.2021.100981 (date from earlier preprint), NCT04348409 (history)
22 Jan 2021    Source   PDF   Share   Tweet
RCT with 25 nitazoxanide patients and 25 control patients, showing improved virological and clinical outcomes with treatment.
Authors also perform an in vitro study in Vero E6 cells showing 90% inhibition with 0.5µM, with no cytotoxicity. NCT04348409 (history).
risk of death, 66.7% lower, RR 0.33, p = 0.25, treatment 2 of 25 (8.0%), control 6 of 25 (24.0%), NNT 6.3.
risk of mechanical ventilation, 62.5% lower, RR 0.38, p = 0.17, treatment 3 of 25 (12.0%), control 8 of 25 (32.0%), NNT 5.0.
relative severity scores, 20.2% better, RR 0.80, treatment 25, control 25.
hospitalization time, 55.7% lower, relative time 0.44, p = 0.02, treatment 25, control 25.
risk of no viral clearance, 89.8% lower, RR 0.10, p = 0.03, treatment 0 of 23 (0.0%), control 4 of 19 (21.1%), NNT 4.8, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 21.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Blum et al., 22 Jan 2021, Double Blind Randomized Controlled Trial, Brazil, peer-reviewed, 17 authors, trial NCT04348409 (history).
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