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0 0.5 1 1.5 2+ Mortality 88% Improvement Relative Risk Ventilation 97% Hospitalization 99% c19nitazoxanide.com Cadegiani et al. Nitazoxanide for COVID-19 EARLY Favors nitazoxanide Favors control
Cadegiani, 494 patient nitazoxanide early treatment study: 88% lower mortality [p=0.08], 97% lower ventilation [p<0.0001], and 99% lower hospitalization [p<0.0001] https://c19p.org/cadegianin
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Early COVID-19 Therapy with azithromycin plus nitazoxanide, ivermectin or hydroxychloroquine in Outpatient Settings Significantly Improved COVID-19 outcomes compared to Known outcomes in untreated patients
Cadegiani et al., New Microbes and New Infections, doi:10.1016/j.nmni.2021.100915 (date from earlier preprint)
4 Nov 2020    Source   PDF   Share   Tweet
Comparison of HCQ, nitazoxanide, and ivermectin showing similar effectiveness for overall clinical outcomes in COVID-19 when used before seven days of symptoms, and overwhelmingly superior compared to the untreated COVID-19 population, even for those outcomes not influenced by placebo effect, at least when combined with azithromycin, and vitamin C, D and zinc in the majority of the cases. 585 patients with mean treatment delay 2.9 days. There was no hospitalization, mechanical ventilation, or mortality with treatment. Control group 1 was a retrospectively obtained group of untreated patients of the same population.
risk of death, 87.8% lower, RR 0.12, p = 0.08, treatment 0 of 357 (0.0%), control 2 of 137 (1.5%), NNT 68, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), control group 1.
risk of mechanical ventilation, 97.0% lower, RR 0.03, p < 0.001, treatment 0 of 357 (0.0%), control 9 of 137 (6.6%), NNT 15, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), control group 1.
risk of hospitalization, 99.0% lower, RR 0.01, p < 0.001, treatment 0 of 357 (0.0%), control 27 of 137 (19.7%), NNT 5.1, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), control group 1.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Cadegiani et al., 4 Nov 2020, prospective, Brazil, peer-reviewed, 4 authors, average treatment delay 2.9 days.
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