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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 68% Improvement Relative Risk Mechanical ventilation 87% ICU admission 59% Hospitalization time 52% c19nitazoxanide.com/calderon2.html Favors nitazoxanide Favors HCQ
23 November 2021 - Late treatment study
Treatment with hydroxychloroquine vs nitazoxanide in patients with COVID-19: brief report
Calderón et al., PAMJ - Clinical Medicine, doi:10.11604/pamj-cm.2021.7.15.30981 (Peer Reviewed)
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Planned RCT of HCQ vs. HCQ+nitazoxanide which was aborted due to the retracted Surgisphere paper. Authors retrospectively analyze a small set of HCQ vs. nitazoxanide patients (which were protocol deviations in the planned RCT), showing reduced hospitalization time and ICU admission with nitazoxanide.
risk of death, 68.2% lower, RR 0.32, p = 0.38, treatment 1 of 17 (5.9%), control 5 of 27 (18.5%), NNT 7.9.
risk of mechanical ventilation, 86.7% lower, RR 0.13, p = 0.15, treatment 0 of 17 (0.0%), control 4 of 27 (14.8%), NNT 6.8, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of ICU admission, 59.3% lower, RR 0.41, p < 0.001, treatment 0 of 17 (0.0%), control 16 of 27 (59.3%), NNT 1.7, adjusted per study.
hospitalization time, 51.8% lower, relative time 0.48, p = 0.006, treatment 17, control 27.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Calderón et al., 11/23/2021, retrospective, Mexico, North America, peer-reviewed, 7 authors, this trial compares with another treatment - results may be better when compared to placebo.
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