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0 0.5 1 1.5 2+ Viral clearance 56% Improvement Relative Risk c19nitazoxanide.com Medhat et al. NCT04498936 Nitazoxanide RCT EARLY TREATMENT Favors nitazoxanide Favors control
Medhat, 150 patient nitazoxanide early treatment RCT: 56% improved viral clearance [p=0.02] https://c19p.org/medhat
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Sofosbuvir/Ledipasvir in Combination or Nitazoxanide Alone are Safe and Efficient Treatments for COVID-19 Infection: A Randomized Controlled Trial for Repurposing antivirals
Medhat et al., Arab Journal of Gastroenterology, doi:10.1016/j.ajg.2022.04.005, NCT04498936 (history)
6 May 2022    Source   PDF   Share   Tweet
RCT with 77 nitazoxanide, 70 sofosbuvir/ledipasvir, and 73 SOC patients in Egypt, showing faster viral clearance with nitazoxanide and with sofosbuvir/ledipasvir. There was no mortality or progression to severe COVID-19 or ICU admission. Nitazoxanide 500mg qid for 14 days. SOC included vitamin C and zinc.
risk of no viral clearance, 55.5% lower, HR 0.44, p = 0.02, treatment 77, control 73, inverted to make RR<1 favor treatment, Cox proportional hazards.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Medhat et al., 6 May 2022, Randomized Controlled Trial, Egypt, peer-reviewed, 20 authors, study period July 2020 - October 2021, trial NCT04498936 (history).
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