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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mean improvement in Ct 26% Improvement Relative Risk Viral load reduction <.. 38% c19nitazoxanide.com/silva.html Favors nitazoxanide Favors control
5 March 2021 - Early treatment study
Efficacy of Nitazoxanide in reducing the viral load in COVID-19 patients. Randomized, placebo-controlled, single-blinded, parallel group, pilot study
Silva et al., medRxiv, doi:10.1101/2021.03.03.21252509 (Preprint)
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Small RCT with 23 nitazoxanide and 13 control patients showing significantly more patients achieved over 35% reduction in viral load from baseline. NCT04463264.
relative mean improvement in Ct, 26.5% better, RR 0.74, p = 0.36, treatment 23, control 13.
risk of viral load reduction < 35% at day 7, 38.3% lower, RR 0.62, p = 0.08, treatment 12 of 23 (52.2%), control 11 of 13 (84.6%), NNT 3.1.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Silva et al., 3/5/2021, Single Blind Randomized Controlled Trial, Argentina, South America, preprint, 11 authors.
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