Analgesics..
Antiandrogens..
Bromhexine
Budesonide
Cannabidiol
Colchicine
Conv. Plasma
Curcumin
Ensovibep
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Iota-carragee..
Ivermectin
Lactoferrin
Lifestyle..
Melatonin
Metformin
Molnupiravir
Monoclonals..
Nigella Sativa
Nitazoxanide
Nitric Oxide
Paxlovid
Peg.. Lambda
Povidone-Iod..
Quercetin
Remdesivir
Vitamins..
Zinc

Other
Feedback
Home
Home   COVID-19 treatment studies for Nitazoxanide  COVID-19 treatment studies for Nitazoxanide  C19 studies: Nitazoxanide  Nitazoxanide   Select treatmentSelect treatmentTreatmentsTreatments
Melatonin Meta
Bromhexine Meta Metformin Meta
Budesonide Meta Molnupiravir Meta
Cannabidiol Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta Nitric Oxide Meta
Ensovibep Meta Paxlovid Meta
Famotidine Meta Peg.. Lambda Meta
Favipiravir Meta Povidone-Iod.. Meta
Fluvoxamine Meta Quercetin Meta
Hydroxychlor.. Meta Remdesivir Meta
Iota-carragee.. Meta
Ivermectin Meta Zinc Meta
Lactoferrin Meta

Other Treatments Global Adoption
All Studies   All Outcomes   Recent: 
0 0.5 1 1.5 2+ Mortality 66% Improvement Relative Risk Hospitalization 79% Symptomatic case 17% Case -21% primary c19nitazoxanide.com Sokhela et al. NCT04561063 COVER Nitazoxanide RCT Prophylaxis Favors nitazoxanide Favors control
Sokhela, 505 patient nitazoxanide prophylaxis RCT: 66% lower mortality [p=1], 79% lower hospitalization [p=0.5], 17% fewer symptomatic cases [p=0.49], and 21% more cases [p=0.67] https://c19p.org/sokhela
copied to clipboard
Randomized clinical trial of nitazoxanide or sofosbuvir/daclatasvir for the prevention of SARS-CoV-2 infection
Sokhela et al., Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkac266, COVER, NCT04561063 (history)
12 Aug 2022    Source   PDF   Share   Tweet
Prophylaxis RCT 828 high-risk participants in South Africa, showing no significant difference with nitazoxanide and sofosbuvir/daclatasvir treatment. FLU-PRO results were available for 74% of the nitazoxanide arm compared to 54% of the control arm.
risk of death, 65.6% lower, RR 0.34, p = 1.00, treatment 0 of 240 (0.0%), control 1 of 265 (0.4%), NNT 265, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of hospitalization, 79.2% lower, RR 0.21, p = 0.50, treatment 0 of 240 (0.0%), control 2 of 265 (0.8%), NNT 132, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of symptomatic case, 17.0% lower, RR 0.83, p = 0.49, treatment 23 of 240 (9.6%), control 37 of 265 (14.0%), incidence rate ratio .
risk of case, 21.0% higher, RR 1.21, p = 0.67, treatment 23 of 240 (9.6%), control 37 of 265 (14.0%), incidence rate ratio , primary outcome.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Sokhela et al., 12 Aug 2022, Randomized Controlled Trial, South Africa, peer-reviewed, median age 24.0, 11 authors, study period December 2020 - January 2022, trial NCT04561063 (history) (COVER).
Contact: ssokhela@ezintsha.org.
All Studies   All Outcomes   Submit Updates or Corrections
This PaperNitazoxanideAll
Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit