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An open label, adaptive, phase 1 trial of high-dose oral nitazoxanide in healthy volunteers: an antiviral candidate for SARS-CoV-2
Walker et al., Clinical Pharmacology & Therapeutics, doi:10.1002/cpt.2463 (date from earlier preprint), NCT04746183 (history)
11 Sep 2021    Source   PDF   Share   Tweet
Phase I trial of high dose nitazoxanide, 1500mg twice daily, with 14 participants. Treatment was safe and well tolerated. PBPK predictions were confirmed on day 1 but with underprediction at day 5. Median Cmin was above the in vitro target concentration after the first dose and maintained throughout. NCT04746183 (history).
Walker et al., 11 Sep 2021, peer-reviewed, 33 authors, trial NCT04746183 (history).
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