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11 September 2021 - N/A
An open label, adaptive, phase 1 trial of high-dose oral nitazoxanide in healthy volunteers: an antiviral candidate for SARS-CoV-2
Walker et al., Clinical Pharmacology & Therapeutics, doi:10.1002/cpt.2463 (preprint 9/11/2021) (Peer Reviewed)
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Phase I trial of high dose nitazoxanide, 1500mg twice daily, with 14 participants. Treatment was safe and well tolerated. PBPK predictions were confirmed on day 1 but with underprediction at day 5. Median Cmin was above the in vitro target concentration after the first dose and maintained throughout. NCT04746183.
Walker et al., 9/11/2021, peer-reviewed, 33 authors.
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